How to Answer "What Sets You Apart from the Rest"

An extremely common interview question these days is some form of "What sets you apart from the rest of the candidates for this job?" Other incarnations of this question include "Why should we hire you?" and "What makes you so different from all the other people interviewing for this position?" No matter exactly how this question is worded, it's getting at the same thing: what are your greatest strengths and skills, what might make you unique, and how those strengths and skills and uniqueness will translate into success in the position you're interviewing for.